Genetics of Musculoskeletal Disease – Prof. David Karasik
Office Phone Number: +972-72-2644-958
The Musculoskeletal Genetics Lab was established in 2011 at the new Faculty of Medicine in the Galilee by David Karasik, Associate Professor. The Lab’s research focuses on the heritable musculoskeletal disorders of aging, such as osteoporosis, osteoarthritis, muscle loss (sarcopenia), and fatty infiltration of muscle and liver. Our search for genes underlying variation in risk of these common diseases, which began with the genome-wide association studies (GWAS) in human populations, is reinforced by validation using functional experiments in animal models (murine and piscine), based on homology between the species and evolutionary theory.
תאור התפקיד: תלמיד לתואר דוקטור
Doctoral student in the field of bone-muscle molecular interactions
PhD candidate position is now available at the Faculty of Medicine of Bar-Ilan University in the Galilee, for graduate students interested in perusing interdisciplinary research in the field of evolution and morphology of musculoskeletal system.
Our group is performing an extensive research of human skeletal diseases using human imaging data and animal models, including murine and piscine (zebrafish). In particular, the candidate will:
– perform musculoskeletal system imaging of the animal locomotor systems, analyze and integrate in-vivo imaging of micro-CT and micro-PET scans in order to explore bone-muscle interactions in health and disease.
Preference will be given to candidates with experience in radiation-based preclinical imaging modalities such as micro-CT and micro-PET. Knowledge of anatomy (human or vertebrate) and interest in animal models is necessary. Teaching is an integral part of this position, focused on anatomy and histology courses in medical school.
The position is at the Faculty of Medicine of BIU in Safed, in the Galilee region of Israel. Information about the School and the Lab can be found here: http://medicine.biu.ac.il/en, and here: http://medweb.md.biu.ac.il/research/david-karasik/
תאור התפקיד: תלמיד לתואר שני בתחום אנטומיה השוואתית של שריר-עצם
Graduate student in the field of bone-muscle molecular interactions
M.Sc.candidate position is now available at the Faculty of Medicine of Bar-Ilan University in the Galilee, for a student interested in pursuing interdisciplinary research in the field of genetic regulation of musculoskeleton in norm and disease.
Our group is performing an extensive research of human skeletal diseases using human patient data and animal models, especially zebrafish (D. rerio). Our aim is to provide a functional validation for the potentially-pleiotropic genes discovered by association studies in humans, by in-vitro and in-vivo experiments. Characterization of muscle and bone phenotypes is performed by advanced imaging techniques (microCT, fluorescent microscopy etc.) The research is performed in collaboration with the EU and US-based colleagues; there is a possibility of training abroad.
In particular, the candidate will:
– implement animal modeling of disease outcomes (with a focus on zebrafish);
– detect effects of the genes identified by association study on the musculoskeletal system by tracing expression levels in cell lines and primary bone and muscle cells
– estimate effects of potentially pleiotropic genes significantly expressed in bone and muscle cells, by genetic engineering in zebrafish (CRISPR, shRNA etc.).
The position requires an experience in general molecular biology protocols.
The position is at the Faculty of Medicine of BIU in Safed, in the Galilee region of Israel. Information about the School and the Lab can be found here: http://medicine.biu.ac.il/en, and here: https://research.med-biu.org/labs/david-karasik/